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Sepsis is defined as SIRS in response to an infectious process. [48] Severe sepsis is defined as sepsis with sepsis-induced organ dysfunction or tissue hypoperfusion (manifesting as hypotension, elevated lactate, or decreased urine output). Severe sepsis is an infectious disease state associated with multiple organ dysfunction syndrome (MODS) [9]
Septic shock is a result of a systemic response to infection or multiple infectious causes. The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
"Sepsis is an overwhelming body reaction for any infection and sepsis is a life-threatening condition," Rangaswamy said. "If not diagnosed early and not treated, it can cause significant mortality ...
Sepsis is often mistaken for flu in the early stages. Experts reveal the key signs of infection that suggest you need urgent medical attention Five signs of sepsis you need to know and act on ...
Meningococcal disease causes life-threatening meningitis and sepsis conditions. In the case of meningitis, bacteria attack the lining between the brain and skull called the meninges . Infected fluid from the meninges then passes into the spinal cord , causing symptoms including stiff neck, fever and rashes .
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Humans can be infected from a multitude of sources in the community including eating food that has been contaminated. E. coli has the ability to cause a wide variety of illnesses in humans including diarrhea, sepsis, meningitis (inflammation of the membranes surrounding the brain and spinal cord), and urinary tract infections.
Lactic acidosis is commonly found in people who are unwell, such as those with severe heart and/or lung disease, a severe infection with sepsis, the systemic inflammatory response syndrome due to another cause, severe physical trauma, or severe depletion of body fluids. [3]