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Pancreatic polypeptide cells are most active and secrete more pancreatic polypeptide after a meal with high protein, fasting, physical activity, and acute hypoglycemia. These same cells are inhibited by somatostatin, an inhibitory gastrointestinal hormone, and the presence of glucose. [5] Pancreatic Polypeptide From a Mouse Cell
Pancreatic polypeptide regulates pancreatic secretion activities by both endocrine and exocrine tissues. It also affects hepatic glycogen levels and gastrointestinal secretions. Its secretion in humans is increased after a protein meal, fasting , exercise, and acute hypoglycaemia , and is decreased by somatostatin and intravenous glucose .
The endocrine cells constitute the beta cells which make insulin, alpha cells which secrete glucagon, delta cells which secrete somatostatin and the PP-cells which secrete pancreatic polypeptide. [3] Pancreatic progenitor cells have been shown to arise from cells originating from the developing foregut during mammalian development.
Secretor status refers to the presence or absence of water-soluble ABO blood group antigens in a person's bodily fluids, such as saliva, tears, breast milk, urine, and semen. People who secrete these antigens in their bodily fluids are referred to as secretors , while people who do not are termed non-secretors .
Sebaceous glands secrete the skin lubricant sebum. Sebum is secreted onto the hair shaft and it prevents the hair from splitting. It consists mostly of lipids. After the sebum spreads along and up the hair shaft, it is distributed over the skin surface where it lubricates and waterproofs the outer layer of the skin, the stratum corneum. [1] [2]
Vasoactive intestinal peptide, also known as vasoactive intestinal polypeptide or VIP, is a peptide hormone that is vasoactive in the intestine. VIP is a peptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, the ligand of class II G protein–coupled receptors. [5]
Beta cells (β-cells) are specialized endocrine cells located within the pancreatic islets of Langerhans responsible for the production and release of insulin and amylin. [1] Constituting ~50–70% of cells in human islets, beta cells play a vital role in maintaining blood glucose levels. [2] Problems with beta cells can lead to disorders such ...
APUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist A.G.E. Pearse, who developed the APUD concept in the 1960s based on calcitonin-secreting parafollicular C cells of dog thyroid. [1] These cells share the common function of secreting a low molecular weight polypeptide hormone.