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Dobutamine is a direct-acting agent whose primary activity results from stimulation of the β 1-adrenoceptors of the heart, increasing contractility and cardiac output. Since it does not act on dopamine receptors to inhibit the release of norepinephrine (another α 1 agonist), dobutamine is less prone to induce hypertension than is dopamine.
2,5-Dimethoxy-4-butylamphetamine (DOBU) is a lesser-known psychedelic drug and a substituted amphetamine.DOBU was first synthesized by Alexander Shulgin.In his book PiHKAL (Phenethylamines i Have Known And Loved), only low dosages of 2 to 3 mg were tested, with the duration simply listed as "very long".
In humans, DOSB is active at doses of 25 to 30 mg orally. [3] Similarly to DOBU, it is said that there is a "strong stimulation factor, with real and long-lasting sleep disturbance ". [ 3 ] In a subsequent publication however, Alexander Shulgin stated that DOSB was inactive at 25 mg orally. [ 4 ]
Tricyclic antidepressant overdose is poisoning caused by excessive medication of the tricyclic antidepressant (TCA) type. Symptoms may include elevated body temperature, blurred vision, dilated pupils, sleepiness, confusion, seizures, rapid heart rate, and cardiac arrest. [1]
Still, he relapsed five days after graduating from the clinic. It would take him another year and a half, along with a platoon of understanding adults, before he found sobriety through another 12-step program. Now, as a physician, he knew he had to track down the clinic’s dropouts and their families, and ask them what Hazelden was doing wrong.
A Minnesota doctor who has worked as a poison specialist is accused of killing his estranged wife by poisoning her, police said. Connor Bowman, 30, of Rochester was arrested Friday, jail records ...
Likewise, it was inactive in humans at oral doses of up to 25 mg. [3] [6] [11] [12] [13] On the other hand, it did still produce hyperthermia in rabbits similarly to other DOx drugs, albeit with dramatically reduced potency. [14] [10] [6] DOTB was first described in the scientific literature by 1974. [14]
A poison specialist and former medical resident at Mayo Clinic in Minnesota is charged with fatally poisoning his wife, a 32-year-old pharmacist who died days after she went to a hospital in ...