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Stomach pumping; General supportive measures; Haemodialysis, which is moderately effective in clearing co-trimoxazole from the plasma. Calcium folinate treatment in cases of blood dyscrasias; Forcing oral fluids; Alkalinisation of the urine may reduce the toxicity of sulfamethoxazole, but it may increase the toxic effects of trimethoprim. [3]
Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and tularemia. All aminoglycosides are ineffective when taken orally as the stomach will digest the drug before it goes into the bloodstream.
Trimethoprim may cause sun sensitivity. [1] There is evidence of potential harm during pregnancy in some animals but not humans. [3] It works by blocking folate metabolism via dihydrofolate reductase in some bacteria, preventing creation of bacterial DNA and RNA and leading to bacterial cell death. [1] Trimethoprim was first used in 1962. [4]
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The cause: The digestive system's natural contractions are felt more severely on an empty stomach. Without food, the stomach becomes a sort of gastric echo chamber. Without food, the stomach ...
An antimicrobial is an agent that kills microorganisms (microbicide) or stops their growth (bacteriostatic agent). [1] Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. For example, antibiotics are used against bacteria, and antifungals are used against fungi. They can also be classified ...
Peptostreptococcus spp. can cause infections such as gluteal decubitus ulcers, diabetes-related foot infections, and rectal abscesses. Anaerobic gram-positive cocci and microaerophilic streptococci are part of the normal skin microbiota, so it is hard to avoid contamination by these bacteria when obtaining specimens. [8] [9]