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Gas gangrene (also known as clostridial myonecrosis [1]) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by Clostridium perfringens bacteria. About 1,000 cases of gas gangrene are reported yearly in the United States. [2] Myonecrosis is a condition of necrotic damage, specific to ...
Gangrene itself happens when the tissue loses blood flow and becomes deprived of oxygen and nutrients. Without proper blood supply, cells in the affected area start dying, leading to decay. There are different types of gangrene, including dry, wet, and gas gangrene, depending on the underlying cause and the conditions of the tissue.
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This toxin has been shown to be the key virulence factor in infection with C. perfringens; the bacterium is unable to cause disease without this toxin. [1] Further, vaccination against the alpha toxin toxoid protects mice against C. perfringens gas gangrene. [2]
They are considered a virulence factor, facilitating the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs. [1] Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large ...
Gangrene of the skin: Specialty: Dermatology: Dermatitis gangrenosa is a cutaneous condition caused by infection by Clostridium resulting in a necrosis and sloughing ...
She is also known for preparing, during 1935–1936, the standard for gas gangrene toxins and anti-toxins. [11] One of Bengtson's other research interests was typhus , an exceedingly dangerous interest and she, like many other typhus researchers, eventually contracted the disease, although she recovered fully. [ 11 ]
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