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For example, Notch has been found to promote the expression of cyclin D3 and Cdk4/6 in human T-cells, thereby promoting the phosphorylation of Rb and facilitating the G1/S transition, implicating its role in cancer as several gain-of-function mutations in NOTCH1 have been identified in human acute T-cell lymphoblastic leukemias and lymphomas.
More recently, JAG1 expression changes have been implicated in many types of cancer. Specifically, up regulation of JAG1 has been correlated with both poor overall breast cancer survival rates and an enhancement of tumor proliferation in adrenocortical carcinoma patients. [13] [27] [28] [29]
4851 18128 Ensembl ENSG00000148400 ENSMUSG00000026923 UniProt P46531 Q01705 RefSeq (mRNA) NM_017617 NM_008714 RefSeq (protein) NP_060087 NP_032740 Location (UCSC) Chr 9: 136.49 – 136.55 Mb Chr 2: 26.35 – 26.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neurogenic locus notch homolog protein 1 (Notch 1) is a protein encoded in humans by the NOTCH1 gene. Notch 1 is a single ...
Most telling perhaps is that 70-80% of breast cancer patients receiving chemotherapy based on traditional predictors would have survived without it. [3] [4] Of note, similar gene expression patterns associated with metastatic behaviour of breast cancer tumor cells have also been found in breast cancer of dog, the most common tumor of the female ...
Drosophila contain a single Notch protein, C.elegans contain two redundant notch paralogs, Lin-12 [25] and GLP-1, [18] [26] and humans have four Notch variants, Notch 1-4. . Although variations exist between homologs, there are a set of highly conserved structures found in all Notch family p
In several types of cancer, a loss of Numb expression has been demonstrated. This is well-established in breast cancer, where a loss of Numb correlates with a worse prognosis. [24] Numb loss has also been demonstrated in Non-small-cell lung carcinoma, salivary gland carcinoma, and chronic myelogenous leukemia. Restoration of Numb function, or ...
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