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For example, Notch has been found to promote the expression of cyclin D3 and Cdk4/6 in human T-cells, thereby promoting the phosphorylation of Rb and facilitating the G1/S transition, implicating its role in cancer as several gain-of-function mutations in NOTCH1 have been identified in human acute T-cell lymphoblastic leukemias and lymphomas.
4851 18128 Ensembl ENSG00000148400 ENSMUSG00000026923 UniProt P46531 Q01705 RefSeq (mRNA) NM_017617 NM_008714 RefSeq (protein) NP_060087 NP_032740 Location (UCSC) Chr 9: 136.49 – 136.55 Mb Chr 2: 26.35 – 26.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neurogenic locus notch homolog protein 1 (Notch 1) is a protein encoded in humans by the NOTCH1 gene. Notch 1 is a single ...
JAG1 was first identified as a ligand that was able to activate notch receptors when the rat gene Jagged encoding a protein homolog was cloned in 1995. [5] [6] The structure of the JAG1 protein includes a small intracellular component, a transmembrane motif, proceeded by an extracellular region containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and finally a signal peptide ...
Moreover, breast cancer risk is heightened following use of the combined oral contraceptive pill and combined hormone replacement therapy. [4] Armed with this evidence that endogenous and exogenous changes in estrogen and progesterone levels modulate the risk of breast cancer, it is apparent that hormones can play a key role in breast cancer.
According to PubMed, a search engine offering access to the MEDLINE database of citations and abstracts of biomedical research articles, 7918 papers containing the expression «breast cancer» were published in 2006. Their number was 3592 in 1996, 1455 in 1986 and only 626 in 1976.
Drosophila contain a single Notch protein, C.elegans contain two redundant notch paralogs, Lin-12 [25] and GLP-1, [18] [26] and humans have four Notch variants, Notch 1-4. . Although variations exist between homologs, there are a set of highly conserved structures found in all Notch family p
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