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Those who are allergic to other β-lactam have a low rate of allergy to aztreonam. [2] Use in pregnancy appears to be safe. [2] It is in the monobactam family of medications. [2] Aztreonam inhibits cell wall synthesis by blocking peptidoglycan crosslinking to cause bacterial death. [2] Aztreonam was approved for medical use in the United States ...
Aztreonam is the archetypal monobactam. [6] Other monobactams include tigemonam, [7] nocardicin A, carumonam and tabtoxin. An example of a monobactam that lacks antibiotic activity, but is used clinically for other purposes, is the cholesterol absorption inhibitor ezetimibe which is used to treat hypercholesterolemia. [8]
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
Treating allergy symptoms with over-the-counter medication, saline spray, and, if warranted, allergy medication or injections from your doctor, may also help reduce GI symptoms as a result.
Aztreonam/avibactam, sold under the brand name Emblaveo (by Pfizer), is a combination of aztreonam, a β-lactam antibiotic, and avibactam, a β-Lactamase inhibitor, developed by AbbVie and Pfizer for aerobic Gram-negative infections.
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
The structure of a Streptomyces serine β-lactamase (SBLs) is given by 1BSG.The alpha-beta fold (InterPro: IPR012338) resembles that of a DD-transpeptidase, from which the enzyme is thought to have evolved. β-lactam antibiotics bind to DD-transpeptidases to inhibit bacterial cell wall biosynthesis.
Aztreonam: Azactam: Gram-negative bacteria: Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Nitrofurans; Furazolidone: Furoxone: Bacterial or protozoal diarrhea or enteritis: Nitrofurantoin(Bs) Macrodantin, Macrobid: Urinary tract infections: Oxazolidinones(Bs ...