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  2. Ezetimibe - Wikipedia

    en.wikipedia.org/wiki/Ezetimibe

    Ezetimibe, sold under the brand name Zetia among others, is a medication used to treat high blood cholesterol and certain other lipid abnormalities. [ 3 ] [ 4 ] Generally it is used together with dietary changes and a statin . [ 5 ]

  3. Onset of action - Wikipedia

    en.wikipedia.org/wiki/Onset_of_action

    A few drugs such as alcohol are absorbed by the lining of the stomach, and therefore tend to take effect much more quickly than the vast majority of oral medications which are absorbed in the small intestine. Gastric emptying time can vary from 0 to 3 hours, [2] and therefore plays a major role in onset of action for orally administered drugs ...

  4. Ezetimibe/simvastatin - Wikipedia

    en.wikipedia.org/wiki/Ezetimibe/simvastatin

    It is a combination of ezetimibe (known as Zetia in the United States) and the statin drug simvastatin (known as Zocor in the US). Ezetimibe reduces blood cholesterol by acting at the brush border of the small intestine and inhibiting the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver.

  5. Pharmacodynamics - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics

    The duration of action of a drug is the length of time that particular drug is effective. [5] Duration of action is a function of several parameters including plasma half-life, the time to equilibrate between plasma and target compartments, and the off rate of the drug from its biological target. [6]

  6. Clearance (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Clearance_(pharmacology)

    The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time. Usually, clearance is measured in L/h or mL/min. [2] Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and ...

  7. IC50 - Wikipedia

    en.wikipedia.org/wiki/IC50

    Due to the minus sign, higher values of pIC 50 indicate exponentially more potent inhibitors. pIC 50 is usually given in terms of molar concentration (mol/L, or M), thus requiring IC 50 in units of M. [2] The IC 50 terminology is also used for some behavioral measures in vivo, such as the two bottle fluid consumption test.

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  9. Chronaxie - Wikipedia

    en.wikipedia.org/wiki/Chronaxie

    The chronaxie values for mammalian ventricles at body temperature range from 0.5 ms (human) to 2.0 to 4.1 ms (dog); this is an 8.2/1 ratio. It has been reported that large-diameter myelinated axons have chronaxie times ranging from 50 to 100 μs and 30 to 200 μs, and neuronal cell bodies and dendrites have chronaxie times ranging from 1 to 10 ...