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GENCODE is a scientific project in genome research and part of the ENCODE (ENCyclopedia Of DNA Elements) scale-up project. The GENCODE consortium was initially formed ...
Gene Codes Corporation is a privately owned international firm based in Ann Arbor, Michigan, which specializes in bioinformatics software for genetic sequence analysis.Its flagship software product, Sequencher, is a sequencing software used throughout the world.
The CCDS dataset is an integral part of the GENCODE gene annotation project [11] and it is used as a standard for high-quality coding exon definition in various research fields, including clinical studies, large-scale epigenomic studies, exome projects and exon array design. [3]
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The Encyclopedia of DNA Elements (ENCODE) is a public research project which aims "to build a comprehensive parts list of functional elements in the human genome." [2]ENCODE also supports further biomedical research by "generating community resources of genomics data, software, tools and methods for genomics data analysis, and products resulting from data analyses and interpretations."
In the 1970s, Tunnicliffe led the development of a standard called GenCode for the publishing industry and later was the first chairman of the International Organization for Standardization committee that created SGML, the first standard descriptive markup language. Book designer Stanley Rice published speculation along similar lines in 1970. [10]
Efforts to understand how proteins are encoded began after DNA's structure was discovered in 1953. The key discoverers, English biophysicist Francis Crick and American biologist James Watson, working together at the Cavendish Laboratory of the University of Cambridge, hypothesied that information flows from DNA and that there is a link between DNA and proteins. [2]
By doing that, the differences in transcripts annotation between RefSeq and Ensembl/GENCODE annotation systems are reduced. A MANE Select transcripts set are created as a useful universal standard for clinical reporting and comparative or evolutionary genomics.