Ads
related to: hiv integrase mechanism- Patient Assistance Info
Discover If You Are Eligible To
Save On An HIV-1 Treatment Option.
- HIV Treatment FAQs
Find Answers To Frequently Asked
Questions About HIV And Medication.
- Download Patient Brochure
Find Resources With Important Info
About Treatment And Switching.
- HIV Real Patient Stories
Watch The Stories Of People Who
Share Their Treatment Experiences.
- Learn How Treatment Works
Visit The Patient Website To Learn
How An HIV-1 Treatment Works.
- Sign Up For More Info
Learn About An HIV Treatment Option
Sign Up To Receive Information.
- Patient Assistance Info
Search results
Results From The WOW.Com Content Network
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects. [1] Retroviral INs are not to be confused with phage integrases ( recombinases ) used in biotechnology , such as λ phage integrase, as discussed in site ...
The HIV-1 integrase (IN) is a key enzyme in the replication mechanism of retroviruses. [9] It is responsible for the transfer of virally encoded DNA into the host chromosome which is a necessary event in retroviral replication. [10]
The integration of HIV DNA can occur either in dividing or resting cells, and the HIV integrase enzyme can exist in the form of a monomer, dimer, tetramer, and possibly even higher-order forms (such as octomers). Each HIV particle has an estimated 40 to 100 copies of the integrase enzyme.
Integrase inhibitors were initially developed for the treatment of HIV infection, but have been applied to other retroviruses. The class of integrase inhibitors called integrase strand transfer inhibitors (INSTIs) are in established medical use. Other classes, such as allosteric integrase inhibitors (ALLINIs) or integrase binding inhibitors ...
After HIV has bound to the target cell, the HIV RNA and various enzymes, including reverse transcriptase, integrase, ribonuclease, and protease, are injected into the cell. [ 59 ] [ failed verification ] During the microtubule -based transport to the nucleus, the viral single-strand RNA genome is transcribed into double-strand DNA, which is ...
HIV-1 protease or PR is a retroviral aspartyl protease ... an integrase, and a mature HIV-1 PR. ... The catalytic mechanism of a general aspartyl protease, containing ...
Ads
related to: hiv integrase mechanism