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Treatment typically takes place in hospital such as in a burn unit or intensive care unit. [3] [7] Efforts include stopping the cause, pain medication, and antihistamines. [3] [4] Antibiotics, intravenous immunoglobulins, and corticosteroids may also be used. [3] [4] Treatments do not typically change the course of the underlying disease. [3]
The initial skin changes are similar to cellulitis or abscess, so diagnosis in early stages may be difficult. The redness and swelling usually blend into surrounding normal tissues. The overlying skin may appear shiny and tense as well. [8] Later signs more suggestive of necrotizing changes (but only present in less than half of cases) are:
Early stage sepsis-associated purpura fulminans may be reversible with quick therapeutic intervention. [2] [7] Treatment is mainly removing the underlying cause and degree of clotting abnormalities and with supportive treatment (antibiotics, volume expansion, tissue oxygenation, etc.). Thus, treatment includes aggressive management of the ...
Pruritic urticarial papules and plaques of pregnancy (PUPPP), known in the United Kingdom as polymorphic eruption of pregnancy (PEP), [1] is a chronic hives-like rash that strikes some women during pregnancy. Some skin changes are known to occur in people who are pregnant while other skin conditions, or dermatoses, that people have prior to ...
In stage 4, deeper necrosis usually occurs, the fat underneath the skin is completely exposed, and the muscle may also become exposed. In the last two stages the sore may cause a deeper loss of fat and necrosis of the muscle; in severe cases it can extend down to bone level, destruction of the bone may begin, and there may be sepsis of joints.
Ecthyma gangrenosum is a type of skin lesion characterized by vesicles or blisters which rapidly evolve into pustules and necrotic ulcers with undermined tender erythematous border. " Ecthyma " means a pus forming infection of the skin with an ulcer, "gangrenosum" refers to the accompanying gangrene or necrosis.
A pyogenic granuloma or lobular capillary hemangioma [3] is a vascular tumor that occurs on both mucosa and skin, and appears as an overgrowth of tissue due to irritation, physical trauma, or hormonal factors. [4] [5] It is often found to involve the gums, skin, or nasal septum, and has also been found far from the head, such as in the thigh. [6]
Gestational pemphigoid (GP) is a rare autoimmune variant of the skin disease bullous pemphigoid, and first appears in pregnancy. [2] It presents with tense blisters, small bumps, hives and intense itching, usually starting around the navel before spreading to limbs in mid-pregnancy or shortly after delivery. [1]