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Brain atrophy can be classified into two main categories: generalized and focal atrophy. [2] Generalized atrophy occurs across the entire brain whereas focal atrophy affects cells in a specific location. [2] If the cerebral hemispheres (the two lobes of the brain that form the cerebrum) are affected, conscious thought and voluntary processes ...
DRPLA is characterized by marked, generalized brain atrophy and the accumulation of atrophin-1 with expanded glutamine stretches. Mutant atrophin-1 proteins have been found in neuronal intranuclear inclusions (NII) and diffusely accumulated in the neuronal nuclei.
Complications such as pneumonia, heart disease, and physical injury from falls reduce life expectancy; although fatal aspiration pneumonia is commonly cited as the ultimate cause of death for those with the condition. [14] [12] [3] Suicide is the cause of death in about 9% of cases. [3]
Studies have shown that PCA may be a variant of Alzheimer's disease (AD), with an emphasis on visual deficits. [2] [11] Although in primarily different, but sometimes overlapping, brain regions, both involve progressive neural degeneration, as shown by the loss of neurons and synapses, and the presence of neurofibrillary tangles and senile plaques in affected brain regions; this eventually ...
But life expectancies aren’t equal across the US: New York is predicted to have the highest life expectancy in the US by 2050, ranking41st in the world, which would be a drop from 33rd place in ...
A normal centenarian brain, cut in the coronal plane (top left) is compared to a brain with LATE-NC (top right). The hippocampi on both sides are atrophic (shrunken) in the brain with LATE-NC. The bottom 3 panels show photomicrographs of a hippocampus with LATE-NC, stained for phosphorylated TDP-43 protein (TDP-43).
The severity of atrophy sustained from alcohol consumption is proportional to the rate and amount of alcohol consumed during a person's life. [8] Complicated alcoholics may have liver damage that impacts brain structure and function and nutritional deficiencies "that can cause severe brain damage and dysfunction". [4] [8]
A neurological disease refers to any ailment of the central nervous system, including abnormalities of the brain, spinal cord and other connecting nerve fibres. [8] Where millions of people are affected by neurological diseases on a worldwide scale, [8] it has been identified that the number of different types of neurological diseases exceeds six hundred, [9] any of which an individual can incur.