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They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow diet pill" regime. [38] This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day.
Phentermine is used for a short period of time to promote weight loss, if exercise and calorie reduction are not sufficient, and in addition to exercise and calorie reduction. [ 5 ] [ 15 ] Phentermine is approved for up to 12 weeks of use and most weight loss occurs in the first weeks. [ 15 ]
So far, neither of the oral weight loss drugs have demonstrated as high of an efficacy as Lilly’s tirzepatide, which was shown to reduce body weight, on average, by 22.5% after 72 weeks.
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