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The De Simone Formulation is a probiotic formula and manufacturing method developed by Claudio De Simone. [1]The De Simone Formulation has been clinically studied for a variety of health conditions since the 1990s [2] but it has been researched the most for its efficacy in the medical management of chronic intestinal conditions including irritable bowel syndrome (IBS) [3] [4] and inflammatory ...
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The potential efficacy of probiotics to treat AAD depends on the probiotic strains and dosage. [ 100 ] [ 101 ] One review recommended for children L. rhamnosus or Saccharomyces boulardii at 5 to 40 billion colony-forming units/day, given the modest number needed to treat and the likelihood that adverse events are very rare. [ 94 ]
Lacticaseibacillus rhamnosus GG (ATCC 53103) is a strain of L. rhamnosus that was isolated in 1983 from the intestinal tract of a healthy human being; filed for a patent on 17 April 1985, by Sherwood Gorbach and Barry Goldin, [11] the 'GG' derives from the first letters of their surnames. [12]
The definition of prebiotics and the food ingredients that can fall under this classification, has evolved since its first definition in 1995. [3] In its earliest definition, the term prebiotics was used to refer to non-digestible food ingredients that were beneficial to the host through their selective stimulation of specific bacteria within the colon.
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