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The De Simone Formulation is a probiotic formula and manufacturing method developed by Claudio De Simone. [1]The De Simone Formulation has been clinically studied for a variety of health conditions since the 1990s [2] but it has been researched the most for its efficacy in the medical management of chronic intestinal conditions including irritable bowel syndrome (IBS) [3] [4] and inflammatory ...
Bacteriotherapy is the purposeful use of bacteria or their products in treating an illness. [1] Forms of bacteriotherapy include the use of probiotics, microorganisms that provide health benefits when consumed; fecal matter transplants (FMT) [2] /intestinal microbiota transplant (IMT), [3] the transfer of gut microorganisms from the fecal matter of healthy donors to recipient patients to ...
The standard preparation as marketed by Miyarisan Pharmaceutical (Tokyo, Japan) consists of white, marked tablets each containing 0.35 × 10 6 colony forming units (CFU) of C. butyricum MIYAIRI 588 (as active agent). CBM 588 does not establish permanently in the gut, in common with other orally administered probiotic bacteria.
The potential efficacy of probiotics to treat AAD depends on the probiotic strains and dosage. [ 100 ] [ 101 ] One review recommended for children L. rhamnosus or Saccharomyces boulardii at 5 to 40 billion colony-forming units/day, given the modest number needed to treat and the likelihood that adverse events are very rare. [ 94 ]
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