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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
Sleep onset is the transition from wakefulness into sleep. Sleep onset usually transits into non-rapid eye movement sleep (NREM sleep) but under certain circumstances (e.g. narcolepsy) it is possible to transit from wakefulness directly into rapid eye movement sleep (REM sleep).
Additionally, any nap opportunity during which REM sleep onset was noted within 15 minutes is marked as a "sleep-onset REM period (SOREMP)." In the appropriate context, more than 1 SOREMP between the preceding PSG and the MSLT may support a diagnosis of narcolepsy. Results must be interpreted cautiously as comorbid sleep disorders, medications ...
For home-testing for an unusually low sleep latency and potential sleep deprivation, the authors point to a technique developed by Nathaniel Kleitman, the "father of sleep research". The subject reclines in a quiet, darkened room and drapes a hand holding a spoon over the edge of the bed or chair, placing a plate on the floor beneath the spoon.
Whether and how long-term REM deprivation has psychological effects remains a matter of controversy. Several reports have indicated that REM deprivation increases aggression and sexual behavior in laboratory test animals. [61] Rats deprived of paradoxical sleep die in 4–6 weeks (twice the time before death in case of total sleep deprivation).
The whole period normally proceeds in the order: N1 → N2 → N3 → N2 → REM. REM sleep occurs as a person returns to stage 2 or 1 from a deep sleep. [20] There is a greater amount of deep sleep (stage N3) earlier in the night, while the proportion of REM sleep increases in the two cycles just before natural awakening. [17]
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