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Onychodystrophy is a deformation of the nails that can result from cancer chemotherapy which includes bleomycin, hydroxyurea, or 5-fluorouracil. It can include discoloration of the nail, or dyschromia. Onychogryposis, also called "ram's-horn nail", is a thickening and increase in curvature of the nail. It is usually the result of injury to the ...
Chromonychia can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia. [2] Although a few cytostatics may cause these changes, the drugs most commonly involved are adriamycin, cyclophosphamide and vincristine, or in polychemotherapy [3] [4] Also chromonychia is associated with AIDS.
2. You buffed your nails too much. Just as moisture-laden nails can be prone to peeling and splitting, so can nails that are dried out from too much buffing, according to Dr. Peters.
Cancer cells can also cause defects in the cellular pathways of apoptosis (programmed cell death). As most chemotherapy drugs kill cancer cells in this manner, defective apoptosis allows survival of these cells, making them resistant. Many chemotherapy drugs also cause DNA damage, which can be repaired by enzymes in the cell that carry out DNA ...
Mees' lines can look similar to injury to the nail, which should not be confused with true Mees' lines. [1] Mees' lines appear after an episode of poisoning with arsenic, [2] thallium or other heavy metals or selenium, [3] opioid MT-45, and can also appear if the subject is suffering from kidney failure. [4] They have been observed in ...
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"Constant biting can lead to poor dental occlusion," says Richard Scher, M.D., an expert in nail disorders, "so the biter's teeth shift out of position or become oddly shaped."
Onychauxis presents with thickened nails without deformity, and this simple thickening may be the result of trauma, acromegaly, Darier's disease, psoriasis, or pityriasis rubra pilaris, or, in some cases, hereditary. [1]: 783 [2] It may appear as loss of nail palate translucency, discoloration, and subungual hyperkeratosis.