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Estrone sulfate, also known as E1S, E1SO4 and estrone 3-sulfate, is a natural, endogenous steroid and an estrogen ester and conjugate. [1] [2] [3]In addition to its role as a natural hormone, estrone sulfate is used as a medication, for instance in menopausal hormone therapy; for information on estrone sulfate as a medication, see the estrone sulfate (medication) article.
Estrone sulfate (E1S) is an estrogen medication and naturally occurring steroid hormone. [1] It is used in menopausal hormone therapy among other indications. [1] [2] As the sodium salt (sodium estrone sulfate), it is the major estrogen component of conjugated estrogens (Premarin) and esterified estrogens (Estratab, Menest).
Estrone (E1), sold under the brand names Estragyn, Kestrin, and Theelin among many others, is an estrogen medication and naturally occurring steroid hormone which has been used in menopausal hormone therapy and for other indications.
Estrogen conjugates are conjugated at the C3, C16α, and/or C17β positions, where hydroxyl groups are available. [1]Estrogen conjugates have been used as pharmaceutical estrogens, as in estrone sulfate as estropipate (piperazine estrone sulfate) and in conjugated estrogens (Premarin) and conjugated estriol (Progynon, Emmenin).
An additional 21% of estrone sulfate is converted into estrone, whereas transformation of estrone into estrone sulfate is approximately 54%. [12] The interconversion between estradiol and estrone is mediated by 17β-hydroxysteroid dehydrogenases (17β-HSDs), [12] whereas the conversion of estrone into estrone sulfate is mediated by estrogen ...
Estradiol sulfate (E2S), or 17β-estradiol 3-sulfate, [1] is a natural, endogenous steroid and an estrogen ester. [2] E2S itself is biologically inactive, [ 3 ] but it can be converted by steroid sulfatase (also called estrogen sulfatase) into estradiol , which is a potent estrogen .
The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the ... E1S; Estrone 3-sulfate <1 <1 >10 >10: Metabolite ...
In another study, a dosage of 1 mg/day oral micronized estradiol in healthy older men, which increased circulating estradiol levels by a relatively high amount of 6-fold (to 159 pg/mL), estrone levels by 15-fold (to 386 pg/mL), and SHBG levels by 17%, was found to suppress total testosterone levels by 27% (to 436 ng/dL) and free testosterone ...