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The Meyer-Overton correlation for anaesthetics. A nonspecific mechanism of general anaesthetic action was first proposed by Emil Harless and Ernst von Bibra in 1847. [9] They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia.
The MGH Department of Anesthesia, Critical Care and Pain Medicine traces its roots back to the October 16, 1846 public demonstration of medical ether. Edward Gilbert Abbott (1825–1855) was the patient upon whom William T. G. Morton first publicly demonstrated the use of ether as a surgical anesthetic.
Ether Day, or The First Operation Under Ether (Robert C. Hinckley, 1882–1893) is on display at UMass Chan Medical School's Lamar Soutter library. Painter Robert Cutler Hinckley meticulously researched the event, particularly who was present and participating, for his The First Operation with Ether (1882–1893). He interviewed various Boston ...
However his attempt to replicate these results at Massachusetts General Hospital (MGH) resulted in a partial anesthetic and was deemed a failure. William T.G. Morton is credited with successfully demonstrating surgical anesthesia for the first time on October 16, 1846, at MGH. Following this event, the use of ether and other volatile ...
On 30 March 1842, he administered diethyl ether by inhalation to a man named James Venable, in order to remove a tumor from the man's neck. [101] Long later removed a second tumor from Venable, again under ether anesthesia. He went on to employ ether as a general anesthetic for limb amputations and childbirth. Long, however, did not publish his ...
Since 1982, ether is not used in the United States. [7] Now, because of the use of intravenous induction agents with muscle relaxants and the discontinuation of ether, elements of Guedel's classification have been superseded by depth of anaesthesia monitoring devices such as the BIS monitor; [5] however, the use of BIS monitoring remains ...
Enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s [2] but is no longer in common use. [3] Enflurane is a structural isomer of isoflurane. It vaporizes ...
William Thomas Green Morton (August 9, 1819 – July 15, 1868) was an American dentist and physician who first publicly demonstrated the use of inhaled ether as a surgical anesthetic in 1846.