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Thymulin (also known as thymic factor or its old name facteur thymique serique) is a nonapeptide produced by two distinct epithelial populations in the thymus first described by Bach in 1977. [1] It requires zinc for biological activity. Its peptide sequence is H-Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH.
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Monomeric β-thymosins, i.e. those of molecular weight similar to the peptides originally isolated from thymus by Goldstein, are found almost exclusively in cells of multicellular animals. [4] Known exceptions are monomeric thymosins found in a few single-celled organisms, significantly those currently regarded as the closest relatives of ...
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Known as "Thymosin Fraction 5", this was able to restore some aspects of immune function in animals lacking thymus gland. Fraction 5 was found to contain over 40 small peptides (molecular weights ranging from 1000 to 15,000 Da.), [ 4 ] which were named "thymosins" and classified as α, β and γ thymosins on the basis of their behaviour in an ...
In the thymus, they undergo a process of maturation, which involves ensuring the cells react against antigens ("positive selection"), but that they do not react against antigens found on body tissue ("negative selection"). [11] Once mature, T cells emigrate from the thymus to provide vital functions in the immune system. [11] [12]
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