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PCR inhibitors are any factor which prevent the amplification of nucleic acids through the polymerase chain reaction (PCR). [1] PCR inhibition is the most common cause of amplification failure when sufficient copies of DNA are present. [2] PCR inhibitors usually affect PCR through interaction with DNA or interference with the DNA polymerase.
DNA polymerase and ribonucleotide reductase inhibitor. Acute myeloid leukaemia , chronic lymphocytic leukaemia , non-Hodgkin lymphoma and Waldenstrom macroglobulinaemia . Myelosuppression, hyperglycaemia , GI bleeds (uncommon), pneumonitis (uncommon), haemolytic anaemia (uncommon), severe neurotoxicity (rare), haemorrhagic cystitis (rare ...
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers . [ 1 ]
Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. [ 1 ] Members of PARP family
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD + ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. [5] It is the most abundant of the PARP family of enzymes, accounting for 90% of the NAD+ used by the family. [ 6 ]
DNA polymerase inhibitors (4 P) N. Nitrogen mustards (1 C, 41 P) T. Topoisomerase inhibitors (2 C, 38 P) Pages in category "DNA replication inhibitors"
Pages in category "DNA polymerase inhibitors" The following 4 pages are in this category, out of 4 total. This list may not reflect recent changes. A. Amikhelline;
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase that is required for replication of HIV and other retroviruses .