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Estradiol levels with rectal administration of estradiol in women after a single 1 mg dose 3 hours post-dose, with 0.5 mg/day 6 hours after the last dose, and with 1 mg/day 6 hours after the last dose. [261] [72] [242] [70] Estradiol has been assessed for use by rectal administration in a number of studies.
The slow release of estradiol valerate is caused by the increased lipophilicity of the medication, which in turn is due to its long fatty acid valeric acid ester moiety. [4] The elimination half-life of estradiol valerate in oil by intramuscular injection (brand names Estradiol-Depot 10 mg, Progynon Depot-10) is about 3.5 days, with a range of ...
Vaginal tablets, including Vagifem which contains estradiol [6] Vaginal creams, ... This page was last edited on 9 August 2024, at 04:29 (UTC).
Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
Estradiol, the most potent of the three major estrogens, was the last of the three to be identified. [85] [89] It was discovered by Schwenk and Hildebrant in 1933, who synthesized it via reduction of estrone. [85]
Toxicological issues prevented long term use of clomifene and further drug development for other potential applications such as breast cancer treatment and prevention. [ 6 ] It was another ten years before tamoxifen was approved in December 1977, not as a contraceptive but as a hormonal treatment to treat and prevent breast cancer. [ 6 ]