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Jordan's syndrome (JS) or PPP2R5D-related intellectual disability is a rare autosomal dominant neurodevelopmental disorder caused by de novo mutations in the PPP2R5D gene. [2] It is characterized by hypotonia, intellectual disability, and macrocephaly. [3] Children with JS may also have epilepsy or meet criteria for diagnosis with autism ...
There are also a number of other conditions that affect hands, feet, and parts of the face with associated skin color changes that need to be differentiated from acrocyanosis: Raynaud phenomenon, pernio, acrorygosis, erythromelalgia, and blue finger syndrome. The diagnosis may be challenging in some cases, especially when these syndromes co-exist.
The shoes are size 13 'Bred' Air Jordan XIIIs. [1] The word "bred" is shorthand for black and red which was the color of the shoes and the colors of the Chicago Bulls. [1] Michael Jordan of the Chicago Bulls wore the shoes during the second half of game 2 of the 1998 NBA Finals against the Utah Jazz. [1]
Athlete's foot is the most common fungal disease, with possibly more than 50% of the population affected at some time. [2] [4] Tinea manuum accounts for less than 2% of all superficial fungal infections. [2] Tinea manuum is rare in both hands. [2] Scenarios with one foot and two hands, and one foot and one hand, have been described. [15]
Dermatophyte infections occur in up to a quarter of the world's population, of which the hands and feet are most commonly involved. [3] It occurs worldwide. [ 3 ] One large study revealed around 84% of tinea manuum was associated with athlete's foot, of which 80% admitted scratching their feet, and 60% were male, [ 6 ]
Cyanosis is the change of body tissue color to a bluish-purple hue, as a result of decrease in the amount of oxygen bound to the hemoglobin in the red blood cells of the capillary bed. [1] Cyanosis is apparent usually in the body tissues covered with thin skin , including the mucous membranes , lips, nail beds , and ear lobes. [ 1 ]
Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer.
Sometimes hands or fingers will be present but limp due to having no bones or being loosely attached. Legs and feet are also affected similarly to the arms and hands. Individuals with phocomelia will often lack thigh bones, and the hands or feet may be abnormally small or appear as stumps due to their close "attachment to the body". [5]