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Proximal diabetic neuropathy, also known as diabetic amyotrophy, is a complication of diabetes mellitus that affects the nerves that supply the thighs, hips, buttocks and/or lower legs. Proximal diabetic neuropathy is a type of diabetic neuropathy characterized by muscle wasting, weakness, pain, or changes in sensation/numbness of the leg.
The medical term for high blood sugar is hyperglycemia. ... If a medical professional suspects you have type 1 diabetes, they may test your blood for autoantibodies. These are the immune proteins ...
Diabetes is the leading known cause of neuropathy in developed countries, and neuropathy is the most common complication and greatest source of morbidity and mortality in diabetes. A systematic review has found that diabetic peripheral neuropathy affects 30% of diabetes patients. [ 1 ]
It has since been the gold standard for pharmacodynamic studies in diabetes drug development and diagnostics evaluation. [3] In human clinical trials, manual glucose clamps as well as the more modern method of automated glucose clamp find common use. [4]
Sustained higher levels of blood sugar cause damage to the blood vessels and to the organs they supply, leading to the complications of diabetes. [48] Chronic hyperglycemia can be measured via the HbA1c test. The definition of acute hyperglycemia varies by study, with mmol/L levels from 8 to 15 (mg/dL levels from 144 to 270). [49]
When peripheral neuropathy results from diabetes mellitus or prediabetes, blood sugar management is key to treatment. In prediabetes, strict blood sugar control can significantly alter the course of neuropathy. [31] In peripheral neuropathy that stems from immune-mediated diseases, the underlying condition is treated with intravenous ...
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