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The most differentiated tumor would have the lowest score, Gleason 2 (1+1), while the most undifferentiated neoplasm (not resembling native prostate tissue) would have the highest score, Gleason 10 (5+5). Gleason scores range from 2 to 10; by definition there is no score of 0 or 1. [4] [7]
The rabbit test became a widely used bioassay (animal-based test) to test for pregnancy. The term "rabbit test" was first recorded in 1949, and was the origin of a common euphemism, "the rabbit died", for a positive pregnancy test. [4] The phrase was, in fact, based on a common misconception about the test.
Primodos was a hormone-based pregnancy test, produced by Schering AG, and used in the 1960s and 1970s that consisted of two pills that contained norethisterone (as acetate) and ethinylestradiol. [ 1 ] [ 2 ] It detected pregnancy by inducing menstruation in women who were not pregnant.
A later article, independently authored, granted Hogben credit for the principle of using Xenopus to determine gonadotropin levels in a pregnant woman's urine, but not for its usage as a functional pregnancy test. [40] Hormonal pregnancy tests such as Primodos and Duogynon were used in the 1960s and 1970s in the UK and Germany. These tests ...
The hCG test can be used to screen for uterus cancer, or a molar pregnancy, which is when there is abnormal placental growth in the uterus. [9] The hCG test can also be done after a miscarriage to ensure that a molar pregnancy is not present. In men, the hCG test can be used to screen for the presence of testicular cancer. [9]
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Other screening tests, such as the Quad test, can also have false positives and false negatives. Even when the Quad results are positive (or, to be more precise, when the Quad test yields a score that shows at least a 1 in 270 risk of abnormality), usually the pregnancy is normal, but additional diagnostic tests are offered.
Gleason's theorem, mathematical result of particular importance for quantum logic; Gleason grading system, used in evaluating the prognosis of men with prostate cancer; Lev Gleason Publications, New York-based publisher of comic books in the 1940s and early 1950s; Jackie Gleason Bus Depot, Brooklyn, New York; Gleason Building (disambiguation)