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However, it may cover Spravato, an FDA-approved drug deriving from ketamine, for treatment-resistant depression. Currently, the Food and Drug Administration (FDA) only approves ketamine for use as ...
The ketamine-derived drug was first approved in 2019 to be used in combination with antidepressants, and later for patients experiencing suicidal thoughts or actions.
The use of ketamine in the United States for any form of psychiatric treatment is not permitted by the FDA. [25] Since 2010, ketamine has been prescribed off-label to patients with severe depression with the informed consent of patients. [26] In 2019, the FDA approved the use of esketamine (Spravato) as a nasal spray, in conjunction with an ...
FDA approves Johnson & Johnson’s ketamine-derived nasal spray for depression as stand-alone treatment. Beth Greenfield. Updated January 23, 2025 at 10:48 AM.
Ketamine was first synthesized in 1962, derived from phencyclidine in pursuit of a safer anesthetic with fewer hallucinogenic effects. [29] [30] It was approved for use in the United States in 1970. [19] It has been regularly used in veterinary medicine and was extensively used for surgical anesthesia in the Vietnam War. [31]
Esketamine, sold under the brand names Spravato (for depression) and Ketanest (for anesthesia) among others, [10] [12] is the S(+) enantiomer of ketamine. [5] [13] It is a dissociative hallucinogen drug used as a general anesthetic and as an antidepressant for treatment of depression.
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