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Zafirlukast is FDA-approved for the prevention and treatment of asthma in adults and children older than 5 years old. [1] Like other leukotriene receptor antagonists, zafirlukast is thought to be useful for the long-term treatment of asthma, but it is generally less effective than inhaled glucocorticoids as monotherapy (which are the standard of care) or long-acting beta-2 agonists in ...
Beta 2-adrenergic agonists, also known as adrenergic β 2 receptor agonists, are a class of drugs that act on the β 2 adrenergic receptor. Like other β adrenergic agonists , they cause smooth muscle relaxation. β 2 adrenergic agonists' effects on smooth muscle cause dilation of bronchial passages , vasodilation in muscle and liver ...
One of those receptors is CysLT type-1 (CysLT1) and can be found in many different parts of the human airway as well as on pro-inflammatory cells. The CysLT receptors have been linked to the pathophysiology of allergic rhinitis and asthma. [9] Zafirlukast and montelukast are powerful CysLT type-1 receptor antagonists.
The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and receptor), such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting (interaction not between drug and receptor), such as MAOIs, COMT inhibitors, release stimulants, and reuptake inhibitors that increase the levels of endogenous catecholamines.
The 'Fortnight' singer's ex Matty Healy is now engaged to model Gabbriette Bechtel.
Beta adrenergic agonists or beta agonists are medications that relax muscles of the airways, causing widening of the airways and resulting in easier breathing. [1] They are a class of sympathomimetic agents, each acting upon the beta adrenoceptors . [ 2 ]
Jeff Bezos’ rocket company Blue Origin is cutting 10% of its workforce. This week's move comes a month after the debut of Blue Origin’s New Glenn rocket, which reached orbit on its first try.
A photo shows a cell where an alleged North Korean soldier held after being captured by the Ukrainian army on January 11, 2025. Earlier this month, Ukraine captured two North Korean soldiers in Kursk.