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Spironolactone is an acne treatment prescribed by dermatologists. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more.
Spironolactone can take up to three months to show effects, ... First up: Nicotinamide, a form of vitamin B3 that may help acne due to its anti-inflammatory effects.
Spironolactone is one of the acne treatments included in the American Academy of Dermatology treatment guidelines. The drug isn’t generally used as a so-called first-line treatment for acne.
Spironolactone may be more effective than birth control pills in the treatment of acne, and the combination of spironolactone with a birth control pill may have greater effectiveness for acne than either alone. [85] In addition, some clinical research has found that flutamide is more effective than spironolactone in the treatment of acne. [64]
[61] [62] In addition, other studies have found that 100 mg/day spironolactone is significantly or near-significantly inferior to 500 mg/day flutamide in improving symptoms of acne and hirsutism. [ 63 ] [ 64 ] [ 65 ] One study compared placebo and dosages of spironolactone of 50, 100, 150, and 200 mg/day in the treatment of acne in women and ...
Side effects often could not be unambiguously attributed to spironolactone due concomitant use of other medications, particularly birth control pills. Hyperkalemia was rare (14/469; 3.0%) and was "invariably mild and clinically insignificant". Risk of bias was high and quality of evidence was low to very low. Sources: [1]