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The increased fitness translated into weight loss. Over the 12 weeks, the exercise-only group lost 1.7% of their body weight on average, but the weight of the group that took Zocor increased slightly.
From 1996 to 2012, under the trade name Lipitor, atorvastatin became the world's best-selling medication of all time, with more than $125 billion in sales over approximately 14.5 years. [ 116 ] and $13 billion a year at its peak, [ 117 ] Lipitor alone "provided up to a quarter of Pfizer Inc.'s annual revenue for years."
According to the 2015 Cochrane systematic review, atorvastatin showed greater cholesterol-lowering effect in women than in men compared to rosuvastatin. [49] In children, statins are effective at reducing cholesterol levels in those with familial hypercholesterolemia. [50] Their long term safety is, however, unclear.
Part of the power of statins lies in the fact that they cause few side effects. “Generally, about 90 out of 100 people have no trouble with a stain,” says Dr. Blumenthal. These Are the Statin ...
When best-selling cholesterol drug Lipitor fell off the patent cliff in 2011, the question became, "What's next?" A hot new class of treatments called PCSK9 inhibitors want to become the answer.
Fibrates typically lower triglycerides by 20% to 50%. Level of the good cholesterol HDL is also increased. Fibrates may decrease LDL, though generally to a lesser degree than statins. Similar to statins, the risk of muscle damage exists. Nicotinic acid, like fibrates, is also well suited for lowering triglycerides by 20–50%. It may also lower ...