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Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.
Proponents of bioidentical hormone therapy believe that progesterone offers fewer side effects and improved quality of life compared to MPA. [61] The evidence for this view has been questioned; MPA is better absorbed when taken by mouth, with a much longer elimination half-life leading to more stable blood levels [ 62 ] though it may lead to ...
[67] [68] Progesterone differs from progestins in terms of effects in the brain and might have different effects on mood in comparison. [ 2 ] [ 69 ] [ 1 ] The available evidence, although limited, suggests no adverse influence of progesterone on mood when used in menopausal hormone therapy.
The antimineralocorticoid effects of progesterone underlie its ability to lower blood pressure and reduce water and salt retention and its potential application in the treatment of hypertension. [ 38 ] [ 1 ] [ 39 ] [ 35 ] An active metabolite of progesterone, 11-deoxycorticosterone (21-hydroxyprogesterone), is a precursor of aldosterone and has ...
Side effects of NETA include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and others. [6] NETA is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [1]
The most common side effects of the norgestrel include irregular bleeding, headaches, dizziness, nausea, increased appetite, abdominal pain, cramps, or bloating. [2] Norgestrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [6]
Rare side effects may include high potassium levels and blood clots (when taken as a combined oestrogen-progestogen pill), among others. [3] [11] Drospirenone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [1]
Side effects of brexanolone may include sedation, sleepiness, dry mouth, hot flashes, and loss of consciousness. [ 6 ] [ 11 ] It is a neurosteroid and acts as a positive allosteric modulator of the GABA A receptor , the major biological target of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).