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Side effects from intra-articular administration can include joint pain, swelling, lameness, and, rarely, infection of the joint. Intramuscular injection can cause dose-dependent inflammation and bleeding, since PSGAG is an analogue of the anticoagulant heparin. [4] In dogs, this may manifest as bleeding from the nose or as bloody stools. [7]
Pentosan polysulfate, like Adequan, has been shown to improve signs of osteoarthritis. In non-equine models, Pentosan has been shown to increase proteoglycan synthesis, [40] stimulate hyaluronic acid production in osteoarthritic joints (a benefit not shared by PSGAGs), [41] reduce inflammatory cytokines, and improve damaged articular cartilage ...
An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
Bedinvetmab, sold under the brand name Librela is a canine monoclonal antibody used for the control of pain associated with osteoarthritis in dogs. [3] [4] [5] Librela is sponsored by Zoetis.
Glycosaminoglycans vary greatly in molecular mass, disaccharide structure, and sulfation.This is because GAG synthesis is not template driven, as are proteins or nucleic acids, but constantly altered by processing enzymes.
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Estradiol levels over a 24-hour period following a single 0.25, 0.5, or 1 mg dose of sublingual estradiol or a single 0.5 or 1 mg dose of oral estradiol in postmenopausal women. [1] Source: Price et al. (1997). [1]
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