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Ibuprofen (Advil or Motrin), naproxen (Aleve) and aspirin (Bayer or Ecotrin) are common pain relievers that belong to a class of medication called non-steroidal anti-inflammatory drugs (NSAIDs).
COX-2 is an enzyme facultatively expressed in inflammation, and it is inhibition of COX-2 that produces the desirable effects of NSAIDs. [125] When nonselective COX-1/COX-2 inhibitors (such as aspirin, ibuprofen, and naproxen) lower stomach prostaglandin levels, ulcers of the stomach or duodenum and internal bleeding can result. [126]
Magnesium salicylate is a common analgesic [1] and nonsteroidal anti-inflammatory drug (NSAID) [2] used to treat mild to moderate musculoskeletal pain [3] such as in tendons and muscles. [ citation needed ] It is also used to treat joint pain like arthritis , [ 2 ] [ 3 ] general back pain , [ 4 ] and headaches .
Resultant, inhibition of prostaglandin synthesis prevents inflammation. [28] The primary mechanism of action responsible for ketorolac's anti-inflammatory, antipyretic, and analgesic effects is the inhibition of prostaglandin synthesis by competitive blocking of the enzyme cyclooxygenase (COX). Ketorolac is a non-selective COX inhibitor. [29]
The best muscle pain relief creams can create cooling or warming sensations or deliver anti-inflammatory ingredients ... equally effective as ibuprofen gel for reducing osteoarthritis pain and ...
Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. [6] [9] It can be taken orally (swallowed by mouth), inserted rectally as a suppository, injected intramuscularly, injected intravenously, applied to the skin topically, or through eye drops.