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The labeled molecules or radiopharmaceuticals have to be synthesized after the radiofluorine is prepared, as the high energy proton radiation would destroy the molecules. Large amounts of oxygen-18 enriched water are used in positron emission tomography centers, for on-site production of 18 F-labeled fludeoxyglucose (FDG).
The best known explanation of the oxygen effect is the oxygen fixation hypothesis developed by Alexander in 1962, [9] which posited that radiation-induced non-restorable or "fixed" nuclear DNA lesions are lethal to cells in the presence of diatomic oxygen. [10] [11] Recent hypotheses include one based on oxygen-enhanced damage from first ...
The oxygen enhancement ratio (OER) or oxygen enhancement effect in radiobiology refers to the enhancement of therapeutic or detrimental effect of ionizing radiation due to the presence of oxygen. This so-called oxygen effect [ 1 ] is most notable when cells are exposed to an ionizing radiation dose .
One of the major limitations of radiotherapy is that the cells of solid tumors become deficient in oxygen. Solid tumors can outgrow their blood supply, causing a low-oxygen state known as hypoxia. Oxygen is a potent radiosensitizer, increasing the effectiveness of a given dose of radiation by forming DNA-damaging free radicals.
About 75% of the fluorine-18 activity remains in tissues and is eliminated with a half-life of 110 minutes, presumably [citation needed] by decaying in place to O-18 to form [18 O]O-glucose-6-phosphate, which is non-radioactive (this molecule can soon be metabolized to carbon dioxide and water, after nuclear transmutation of the fluorine to ...
Fluorine-18 (18 F, also called radiofluorine) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 96.7% of the time and electron capture 3.3% of the time. Both modes of decay yield stable oxygen-18.
Oxygen (chemical symbol O) has three naturally occurring isotopes: 16 O, 17 O, and 18 O, where the 16, 17 and 18 refer to the atomic mass.The most abundant is 16 O, with a small percentage of 18 O and an even smaller percentage of 17 O. Oxygen isotope analysis considers only the ratio of 18 O to 16 O present in a sample.
The oxygen depletion was thought to be caused by radiolysis of water molecules, where water breaks down into hydrogen peroxide, hydrogen radicals and other oxygen compounds. [ 7 ] [ 8 ] However, experimental studies demonstrated that oxygen depletion does not occur.