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The common biomolecular mechanisms underlying addiction – CREB and ΔFosB – were reviewed by Eric J. Nestler in a 2013 review. [3] Genetics and mental disorders may precipitate the severity of a drug addiction. It is estimated that 50% of healthy individuals developing an addiction can trace the cause to genetic factors. [4]
Norman Earl Zinberg (1922 – April 2, 1989 [1]) was an American psychoanalyst and psychiatrist whose research into addiction is seen as a great influence [weasel words] on current [when?] clinical models and greatly influenced the work of addiction treatment specialists such as Stanton Peele.
The biomedical model of medicine care is the medical model used in most Western healthcare settings, and is built from the perception that a state of health is defined purely in the absence of illness. [1]: 24, 26 The biomedical model contrasts with sociological theories of care. [1]: 1 [2]
Under the model of alcoholism, alcohol use disorder is viewed as chronic problem for which abstinence is required. [4] A brain disease model of addiction, based on the extent of neuroadaptation and impaired control, is main position advanced for proposing a disease model of alcohol use disorder. [5]
Naltrexone, an opioid receptor antagonist, was already in use by the early 1980s as a medication for treating addiction to heroin and other opioids, but not alcohol addiction. Based on animal studies, O'Brien in the 1980s theorized that alcohol produced pleasure by releasing endorphins – the brain's naturally occurring opioids. [ 7 ]
Medical model is the term coined by psychiatrist R. D. Laing in his The Politics of the Family and Other Essays (1971), for the "set of procedures in which all doctors are trained". [1] It includes complaint, history, physical examination, ancillary tests if needed, diagnosis, treatment, and prognosis with and without treatment.
Researchers have been making breakthroughs in addiction medicine for decades. But attempts to integrate science into treatment policy have been repeatedly stymied by scaremongering politics. In the early 1970s, the Nixon administration promoted methadone maintenance to head off what was seen as a brewing public health crisis.
Addiction medicine is a medical subspecialty that deals with the diagnosis, prevention, evaluation, treatment, and recovery of persons with addiction, of those with substance-related and addictive disorders, and of people who show unhealthy use of substances including alcohol, nicotine, prescription medicine and other illicit and licit drugs. [3]