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In the human genome, CCL2 and many other CC chemokines are located on chromosome 17 (17q11.2-q21.1). [8] The gene span is 1,927 bases and the CCL2 gene resides on the Watson (plus) strand. The CCL2 gene has three exons and two introns. The CCL2 protein precursor contains a signal peptide of 23 amino acids. In turn, the mature CCL2 is 76 amino ...
Monocyte chemoattractant protein 1 (MCP1 or MCP-1), cytokine also known as CCL2 Mast cell protease 1 , enzyme also known as chymase Tennelec MCP-1 , an early radio scanner
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically mediates monocyte chemotaxis.Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors.
n/a Ensembl ENSG00000108688 n/a UniProt P80098 n/a RefSeq (mRNA) NM_006273 n/a RefSeq (protein) NP_006264 n/a Location (UCSC) Chr 17: 34.27 – 34.27 Mb n/a PubMed search n/a Wikidata View/Edit Human Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-chemotactic protein 3 (MCP3). CCL7 is a small protein that belongs to the CC chemokine family and is ...
Examples of CC chemokine include monocyte chemoattractant protein-1 (MCP-1 or CCL2) which induces monocytes to leave the bloodstream and enter the surrounding tissue to become tissue macrophages. CCL5 (or RANTES ) attracts cells such as T cells, eosinophils and basophils that express the receptor CCR5 .
These factors include most particularly chemokines such as monocyte chemotactic protein-1 (CCL2) and monocyte chemotactic protein-3 (CCL7); certain arachidonic acid metabolites such as leukotriene B4 and members of the 5-hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid family of OXE1 receptor agonists (e.g., 5-HETE and 5-oxo-ETE ...
This family of agonists stimulates chemotactic responses in human eosinophils, neutrophils, and monocytes by binding to the Oxoeicosanoid receptor 1, which like the receptors for leukotriene B4, is a G protein-coupled receptor. [67]
Zinc finger CCCH-type containing 12A is a protein in humans that is encoded by the ZC3H12A gene. [5]ZC3H12A (also known as MCPIP-1 and Regnase-1) is an MCP1 (CCL2; MIM 158105)-induced protein that plays an important role in cell differentiation, apoptosis and the regulation of inflammation.