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Boric acid is an antiseptic used as a vaginal medication to treat vaginal infections including yeast infections, bacterial vaginosis, and trichomoniasis. [ 5 ] [ 2 ] It is administered as a capsule or suppository inserted into the vagina .
TOL-463 is an anti-infective medication which is under development for the treatment of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) (vaginal yeast infection). [ 3 ] [ 1 ] [ 4 ] [ 2 ] It is a boric acid -based vaginal anti-infective enhanced with ethylenediaminetetraacetic acid (EDTA) which was designed to have improved activity ...
There are a number of reasons for treatment failure. For example, if the infection is a different kind, such as bacterial vaginosis (the most common cause of abnormal vaginal discharge), rather than thrush. [12] Vaginal boric acid has evidence of effectiveness against non-C. albicans species. [28] [29]
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Bacterial vaginosis (BV) is an infection of the vagina caused by excessive growth of bacteria. [ 6 ] [ 12 ] Common symptoms include increased vaginal discharge that often smells like fish. [ 2 ] The discharge is usually white or gray in color. [ 2 ]
Boric acid is a weak acid, with pK a (the pH at which buffering is strongest because the free acid and borate ion are in equal concentrations) of 9.24 in pure water at 25 °C. But apparent p K a is substantially lower in swimming pool or ocean waters because of interactions with various other molecules in solution.