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Chickenpox, also known as varicella (/ ˌ v ɛ r ə ˈ s ɛ l ə / VER-ə-SEL-ə), is a highly contagious disease caused by varicella zoster virus (VZV), a member of the herpesvirus family. [ 3 ] [ 7 ] [ 5 ] The disease results in a characteristic skin rash that forms small, itchy blisters , which eventually scab over. [ 1 ]
Varicella vaccine, also known as chickenpox vaccine, is a vaccine that protects against chickenpox. [9] One dose of vaccine prevents 95% of moderate disease and 100% of severe disease. [ 10 ] Two doses of vaccine are more effective than one. [ 10 ]
A reemergence of the disease in the DRC in 1996 also saw a large number of reported but not all laboratory confirmed cases, with a high transmission rate and lower fatality rate; leading experts to believe a significant number may have actually been chicken pox. [9] [12] Some likely had both mpox and chickenpox at the same time. [5]
The chicken pox vaccine became available in the U.S. in 1995 and, since then, cases of the virus in the U.S. have plummeted. But chicken pox still emerges from time to time. Montana public health ...
The mutation rate in poxvirus genomes has been estimated to be 0.9–1.2 x 10 −6 substitutions per site per year. [20] A second estimate puts this rate at 0.5–7 × 10 −6 nucleotide substitutions per site per year. [21] A third estimate places the rate at 4–6 × 10 −6. [22]
Michiaki Takahashi (高橋 理明, Takahashi Michiaki, February 17, 1928 – December 16, 2013) was a Japanese virologist, best known for inventing the first chickenpox vaccine. He developed the "Oka" vaccine by producing v-Oka, a live-attenuated virus strain of varicella zoster virus. [1]
A zoster vaccine is a vaccine that reduces the incidence of herpes zoster (shingles), a disease caused by reactivation of the varicella zoster virus, which is also responsible for chickenpox. [8] Shingles provokes a painful rash with blisters, and can be followed by chronic pain (postherpetic neuralgia), as well as other complications.
Vaccine Excipients Adenovirus vaccine: This list refers to the type 4 and type 7 adenovirus vaccine tablets licensed in the US: Acetone, alcohol, anhydrous lactose, castor oil, cellulose acetate phthalate, dextrose, D-fructose, D-mannose, FD&C Yellow #6 aluminium lake dye, fetal bovine serum, human serum albumin, magnesium stearate, micro crystalline cellulose, plasdone C, Polacrilin potassium ...