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Molecular orbital diagrams best illustrate isoelectronicity in diatomic molecules, showing how atomic orbital mixing in isoelectronic species results in identical orbital combination, and thus also bonding. More complex molecules can be polyatomic also. For example, the amino acids serine, cysteine, and selenocysteine are all isoelectronic to ...
A DNA segment is identical by state (IBS) in two or more individuals if they have identical nucleotide sequences in this segment. An IBS segment is identical by descent (IBD) in two or more individuals if they have inherited it from a common ancestor without recombination, that is, the segment has the same ancestral origin in these individuals.
In 1998 it was determined that homologous pairing in Drosophila occurs through independent initiations (as opposed to a directed, 'processive zippering' motion). [4] [8]The first RNAi screen (based on DNA FISH [9]) was carried out to identify genes regulating D. melanogaster somatic pairing in 2012, [10] described at the time as providing "an extensive “parts list” of mostly novel factors".
Well-studied sets of paralogy regions include regions of human chromosome 2, 7, 12 and 17 containing Hox gene clusters, collagen genes, keratin genes and other duplicated genes, [46] regions of human chromosomes 4, 5, 8 and 10 containing neuropeptide receptor genes, NK class homeobox genes and many more gene families, [47] [48] [49] and parts ...
[1] [2] Pair-rule genes are defined by the effect of a mutation in that gene, which causes the loss of the normal developmental pattern in alternating segments. Pair-rule genes were first described by Christiane Nüsslein-Volhard and Eric Wieschaus in 1980. [3] They used a genetic screen to identify genes required for embryonic development in ...
The SHOX gene in the PAR1 region is the gene most commonly associated with and well understood with regards to disorders in humans, [17] but all pseudoautosomal genes escape X-inactivation and are therefore candidates for having gene dosage effects in sex chromosome aneuploidy conditions (45,X, 47,XXX, 47,XXY, 47,XYY, etc.).
The words homozygous, heterozygous, and hemizygous are used to describe the genotype of a diploid organism at a single locus on the DNA. Homozygous describes a genotype consisting of two identical alleles at a given locus, heterozygous describes a genotype consisting of two different alleles at a locus, hemizygous describes a genotype consisting of only a single copy of a particular gene in an ...
We integrate the identification of bimodal genes in ES cell differentiation with analysis of chromatin state and for kind of then identify clear cell-state dependent patterns of bimodal, bivalent genes. We show that binarization of bimodal genes can be used to identify differentially expressed genes from fractional ON/OFF proportions.