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In most cases, the cells that are dying are recognized by phagocytes through find-me signals and removed. Quick and efficient clearing of apoptotic cells is crucial to prevent secondary necrosis of dying cells and to avoid autoantigens causing immune responses. Find-me signals alert the presence of apoptotic cells to phagocytes when they are in ...
Another mechanism that CLL cells use to avoid destruction involves the use of proteins in the B-cell lymphoma (Bcl-2) family. [45] By blocking the function of those Bcl-2 proteins, targeted drugs can prevent further progression of CLL-related tumors. [45] Some of the most common biological drugs used to treat CLL include:
Estimates based on screening of leukemia-lymphoma cell lines suggest that about 15% of these cell lines are not representative of what they are usually assumed to be. [2] A project is currently underway to enumerate and rename contaminated cell lines to avoid errors in research caused by misattribution. [3] [4] [a]
Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). [7] The name typically refers to just the cancerous versions rather than all such tumours. [7]
Normal B cells of a germinal center possess rearranged immunoglobulin heavy and light chain genes, and each isolated B cell possesses a unique IgH gene rearrangement. Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are supposed to possess identical IgH genes.
Current studies suggest that EBV transforms the B-cells which it infects into rapidly proliferating cells that in the case of FA-DLBCL are able to avoid attack by the immune system because they are in sites devoid of small blood vessels, overloaded with fibrin thrombi and/or debris resulting from the death of cells, and therefore lack inflammatory cells [2] including cytotoxic T-cells, [8] a ...
Transitional cell carcinoma, a type of cancer most commonly seen in a dog's bladder, may respond to ivermectin in the same way as human renal cell carcinoma. Unfortunately, there is not yet any ...
The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases ...
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