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Xanthelasma is a sharply demarcated yellowish deposit of cholesterol underneath the skin. [1] It usually occurs on or around the eyelids ( xanthelasma palpebrarum , abbreviated XP). [ 1 ] [ 2 ] While they are neither harmful to the skin nor painful , these minor growths may be disfiguring and can be removed. [ 1 ]
A xanthelasma is a sharply demarcated yellowish collection of cholesterol underneath the skin, usually on or around the eyelids. Strictly, a xanthelasma is a distinct condition, being called a xanthoma only when becoming larger and nodular, assuming tumorous proportions. [3] Still, it is often classified simply as a subtype of xanthoma. [4]
High cholesterol levels normally do not cause any symptoms. Yellow deposits of cholesterol-rich fat may be seen in various places on the body such as around the eyelids (known as xanthelasma palpebrarum), the outer margin of the iris (known as arcus senilis corneae), and in the tendons of the hands, elbows, knees, and feet, particularly the Achilles tendon (known as a tendon xanthoma).
In the elderly, arcus senilis is a benign condition that does not require treatment. The presence of an arcus senilis in males under the age of 50 may represent a risk factor for cardiovascular disease, [6] and these individuals should be screened for an underlying lipid disorder. The opaque ring in the cornea does not resolve with treatment of ...
The xanthogranulomatous type of inflammation is most-commonly seen in pyelonephritis and cholecystitis, although it has more recently been described in an array of other locations including bronchi, lung, endometrium, vagina, fallopian tubes, ovary, testis, epididymis, stomach, colon, ileum, pancreas, bone, lymph nodes, bladder, adrenal gland, abdomen and muscle. [5]
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The decision by the National Institute for Health and Care Excellence has been hailed by campaigners.
Specifically, Touton giant cells are found in lipid-rich lesions such as those of fat necrosis, xanthoma, xanthelasma and xanthogranulomas. Touton giant cells are also referred to as xanthelasmatic cells due to the fact they are found in lesions associated with xanthomas which are skin growths with yellow, lipid filled deposits.