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Prenatal thyroid theory of same-sex attraction/gender dysphoria has been based on clinical and developmental observations of youngsters presenting to child psychiatry clinics in Istanbul/Turkey. The report of 12 cases with same-sex attraction/gender dysphoria born to mothers with thyroid diseases was first presented in EPA Congress, Vienna ...
The ligand-binding domain of the ER demonstrates how ligands promote and prevent coactivator binding based on the shape of the estrogen or antiestrogen complex. The broad range of ligands that bind to the ER can create a spectrum of ER complexes that are fully estrogenic or antiestrogenic at a specific target site.
Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. [1] The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved.
Progesterone causes many changes to the genitourinary system. A pregnant woman may experience an increase in the size of the kidneys and ureter due to the increase blood volume and vasculature. Later in pregnancy, the woman might develop physiological hydronephrosis and hydroureter, which are normal. [33]
Contraindicated in pregnancy: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Megestrol acetate is the lead drug of this class for the management of cachexia, and medroxyprogesterone acetate is also used. [ 43 ] [ 44 ] The mechanism of action of the appetite-related effects of these two medications is unknown and may not be related to their progestogenic activity.
Resistant reading is an element of some current critical and interpretive repertoire. It is worth considering whether diegetic border crossing always strengthens the potential for resistant reading (as might seem intuitively likely, given that readers are moving in and out of the story), or whether on some occasions it might trigger the reverse effect.
Pregnancy discrimination may also take the form of denying reasonable accommodations to workers based on pregnancy, childbirth, and related medical conditions. [2] Pregnancy discrimination has also been examined to have an indirect relationship with the decline of a mother's physical and mental health. [3]