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MCF-7 cells. MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old woman. [1] MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. [2] The Michigan Cancer Foundation is now known as the Barbara Ann Karmanos Cancer ...
This is a list of major breast cancer cell lines that are primarily used in breast cancer research. ... MCF-7: Invasive ductal carcinoma: Metastasis (pleural effusion ...
In several stable cell lines, it is possible to induce specific estrogen-related proteins. For example, in the human MCF-7 breast cancer cell line the protein pS2 is strongly up-regulated by estrogen. Induction of the pS2 protein can be detected already one hour after estrogen, or a given compound acting as an estrogen, is added to the cells.
[7] NCI/ADR-RES, originally classified as breast cancer cell line, was identified as being an ovarian tumor cell line. [8] NCI/ADR-RES appears to have been derived at some point in time from cell line OVCAR-8. [8] Originally the cell line was named MCF-7/ADR-RES; it was renamed together with the change in classification. [8]
A number of cell lines used to elucidate the role of miR-206 in breast cancer include MCF-7, MDA-MB-231, and MDA-MB-468 cell lines. Single nucleotide polymorphisms (SNPs) can be located in the miRNA seed sequence, and therefore are known to have functional consequences.
Further, the release of photo-activated adriamycin with the aid of nanoporous optical antenna resulted in significant anti-cancer effect in MCF-7 breast cancer cells. [58] In 2006, animal research coupling a murine monoclonal antibody with doxorubicin created an immunoconjugate that was able to eliminate HIV-1 infection in mice. [59] [60]
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