Search results
Results From The WOW.Com Content Network
In addition to the above, there are some less commonly used ACEi that are listed here with their dose equivalence: Fosinopril: 10mg; Moexipril: 7.5mg; Perindopril: 4mg; Quinapril: 10mg; Trandolapril: 1mg; Reference: Greater Rochester Independent Practice Association. Approximate Dose Conversions.
Ace-inhibitor conversions for all of the common ace-inhibitors based on the estimated potency. Drug comparisons based on potency
USUAL ADULT DOSING. Benazepril: 10 mg once daily in patients initial dose (not on a diuretic). Usual dose: 20-40 mg in a single or 2 divided doses. Captopril: HFrEF/ HTN/Left ventricular dysfunction after myocardial infarction (LVD after MI): 6.25-12.5 mg three times a day (with diuretic) with goal of 50 mg three times a day for HFrEF.
Approximate Dose Equivalence Maximum Daily Dose (mg) Captopril (Capoten®) 12.5 mg tid: 150
Excessive doses of ACE inhibitors are usually well-tolerated, but they can cause hypotension, drop-in GFR, and electrolyte derangements. In addition, since ACE inhibitors block aldosterone, they can cause hyperkalemia and hyponatremia.
ACE inhibitors (ACEIs) have Class I (LOE A)* indication for all patients with heart failure with reduced ejection fraction (HFrEF, defined as EF ≤ 40 %) and current or prior symptoms of heart failure (unless contraindicated).
Although many ACE inhibitors are recommended for once daily dosing, for some, such as enalapril, a more consistent response is achieved by twice daily administration. Since duration of blood pressure reduction is dose-dependent, with most ACE inhibitors, smooth blood pressure lowering over 24 hours is only achieved at the maximum recommended dose.
nephropathy (see Table 1). ACE inhibitors (with the exception of captopril and lisinopril) are prodrugs requiring activation through hepatic biotransformation. Most ACEIs have half-lives of 10-12 hours; the shortest-acting are captopril (<2 hours) and quinapril (2 hours), while the longest acting is ramipril (13-17 hours).
Professional / Tables / Oral Angiotensin-Converting Enzyme (ACE) Inhibitors and Angiotensin II Receptor Blockers for Hypertension. Medication. Selected Adverse Effects. ACE inhibitors*
ACE inhibitors and ARBs act by blocking RAAS with beneficial effects on patients with cardiovascular risk factors only (hypertension, diabetes) and with several heart diseases (heart failure, coronary artery disease).