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In epidemiology, the relative risk reduction (RRR) or efficacy is the relative decrease in the risk of an adverse event in the exposed group compared to an unexposed group. It is computed as , where is the incidence in the exposed group, and is the incidence in the unexposed group.
The relative risk reduction is 0.5 (50%), while the absolute risk reduction is 0.0001 (0.01%). The absolute risk reduction reflects the low probability of getting colon cancer in the first place, while reporting only relative risk reduction, would run into risk of readers exaggerating the effectiveness of the drug. [5]
Relative risk is used in the statistical analysis of the data of ecological, cohort, medical and intervention studies, to estimate the strength of the association between exposures (treatments or risk factors) and outcomes. [2] Mathematically, it is the incidence rate of the outcome in the exposed group, , divided by the rate of the unexposed ...
Frequently used measures of risk and benefit identified by Jerkel, Katz and Elmore, [4] describe measures of risk difference (attributable risk), rate difference (often expressed as the odds ratio or relative risk), population attributable risk (PAR), and the relative risk reduction, which can be recalculated into a measure of absolute benefit ...
The trial ran for 3.3 years, and during this period the relative risk of a "primary event" (heart attack) was reduced by 36% (relative risk reduction, RRR). The absolute risk reduction (ARR), however, was much smaller, because the study group did not have a very high rate of cardiovascular events over the study period: 2.67% in the control ...
Hazard ratio. In survival analysis, the hazard ratio (HR) is the ratio of the hazard rates corresponding to the conditions characterised by two distinct levels of a treatment variable of interest. For example, in a clinical study of a drug, the treated population may die at twice the rate per unit time [clarify] of the control population.
In epidemiology, preventable fraction among the unexposed (PF u ), is the proportion of incidents in the unexposed group that could be prevented by exposure. It is calculated as , where is the incidence in the exposed group, is the incidence in the unexposed group, and is the relative risk. [1] [2] It is a synonym of the relative risk reduction .
That unmitigated risk is then compared against a tolerable risk target. The difference between the unmitigated risk and the tolerable risk, if the unmitigated risk is higher than tolerable, must be addressed through risk reduction of provided by the SIF. This amount of required risk reduction is correlated with the SIL target.