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The term cytokeratin began to be used in the late 1970s, when the protein subunits of keratin intermediate filaments inside cells were first being identified and characterized. [2] In 2006 a new systematic nomenclature for mammalian keratins was created, and the proteins previously called cytokeratins are simply called keratins (human ...
Type II Keratins are divided into 2 subtypes: Type IIA Keratins and Type IIB Keratins. Type 2A keratins are expressed in tissues that require high levels of mechanical stress, such as the soles of the feet, while type 2B keratins are expressed in tissues that are subject to less stress, such as the palms of the hands.
Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18 . Utility as an immunohistochemical stain
Keratin, type II cytoskeletal 7 also known as cytokeratin-7 (CK-7) or keratin-7 (K7) or sarcolectin (SCL) is a protein that in humans is encoded by the KRT7 gene. [5] [6] [7] Keratin 7 is a type II keratin. It is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.
Type I keratins (or Type I cytokeratins) are cytokeratins that constitute the Type I intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells.
Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. [8] In immunohistochemistry, antibodies to CK20 can be used to identify a range of adenocarcinoma arising from epithelia that normally contain the CK20 protein.
16661 Ensembl ENSG00000186395 ENSMUSG00000019761 UniProt P13645 P02535 RefSeq (mRNA) NM_000421 NM_001379366 NM_010660 RefSeq (protein) NP_000412 NP_001366295 NP_034790 Location (UCSC) Chr 17: 40.82 – 40.82 Mb Chr 11: 99.28 – 99.28 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein ...
Keratin 14 is a member of the type I keratin family of intermediate filament proteins.Keratin 14 was the first type I keratin sequence determined. [5] Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14).