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There are several different repair options available for cartilage damage or failure. "Maci" or autologous cultured chondrocytes on porcine collagen membrane, is a treatment to correct cartilage defects in the knee. This treatment has been approved by the Food and Drug Administration in 2016 for adult treatment only. [1]
Autologous chondrocyte implantation (ACI, ATC code M09AX02 ()) is a biomedical treatment that repairs damages in articular cartilage.ACI provides pain relief while at the same time slowing down the progression or considerably delaying partial or total joint replacement (knee replacement) surgery.
It is used to treat symptomatic, full-thickness cartilage defects of the knee with or without bone involvement. [2] [1] Autologous cultured chondrocytes on porcine collagen membrane is an autologous cellularized scaffold product. [1] This treatment is approved by the US Food and Drug Administration (FDA). [1] It is only administered to adults. [1]
Marrow-nucleated cells are used every day in regenerative orthopedics. The knee microfracture surgery technique relies on the release of these cells into a cartilage lesion to initiate fibrocartilage repair in osteochondral defects. [13] In addition, this cell population has also been shown to assist in the repair of non-union fractures. [14]
Articular cartilage repair treatment involves the repair of the surface of the articular joint's hyaline cartilage, though these solutions do not perfectly restore the articular cartilage. These treatments have been shown to have positive results for patients who have articular cartilage damage. They can provide some measure of pain relief ...
It is a well documented cartilage repair technique and first line treatment option for small cartilage lesions. [12] [13] [14] AMIC evolved with the aim to improve some of the shortfalls of microfracture surgery as for instance variable repair cartilage volume and functional deterioration over time. [15]