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Vitiligo (/ ˌ v ɪ t ɪ ˈ l aɪ ɡ oʊ /, vi-ti-leye-goh) is a chronic autoimmune disorder that causes patches of skin to lose pigment or color. [1] The cause of vitiligo is unknown, but it may be related to immune system changes, genetic factors, stress, or sun exposure.
Alfred Blaschko, a private practice dermatologist from Berlin, first described and drew the patterns of the lines of Blaschko in 1901. He obtained his data by studying over 140 patients with various nevoid and acquired skin diseases and transposed the visible patterns the diseases followed onto dolls and statues, then compiled the patterns onto a composite schematic of the human body.
The skin will appear paler than the surrounding skin surface once an injury has healed. [4] Different areas of the skin may be hypopigmented as a result of other genetic illnesses. Hypopigmentation can be caused by hereditary conditions such as vitiligo, melasma, pityriasis versicolor, pityriasis alba, albinism, and fungal infections. [4]
Michael’s first child, Michael Joseph Jackson Jr., was born to the musician and nurse Debbie Rowe, […] “He had a lot of insecurity around, kind of looking blotchy in his appearance,” said ...
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Vitiligo occurs in three different patterns. Segmental depigmentation means only one side of the body is affected, whereas generalized depigmentation means many parts of the body are affected. [34] Jackson's autopsy report states a "focal depigmentation of the skin" [35] (i.e., the depigmentation occurs on one or a few areas of the body). [34]
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This results in either the entire surface (if all pigment cells fail to develop) or patches of body surface (if only a subset are defective) having a lack of cells that can make pigment. Since all pigment cell-types differentiate from the same multipotent precursor cell-type, leucism can cause the reduction in all types of pigment.