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Pepto-Bismol is an over-the-counter drug currently produced by the Procter & Gamble company in the United States, Canada and the United Kingdom. Pepto-Bismol is made in chewable tablets [24] and swallowable caplets, [25] but it is best known for its original formula, which is a thick
The active ingredient in Kaopectate has changed since its original creation. Originally, kaolinite was used as the adsorbent and pectin as the emollient. Attapulgite (a type of absorbent clay) replaced the kaolinite in the 1980s, but was banned by the U.S. Food and Drug Administration in a ruling made in April 2003.
Antimotility agents are drugs used to alleviate the symptoms of diarrhea. These include loperamide (Imodium), bismuth subsalicylate (Pepto-Bismol), [1] diphenoxylate with atropine (Lomotil), and opiates such as paregoric, tincture of opium, codeine, and morphine.
In 1944, two clinicians who evaluated the expectorant action of paregoric, concluded: The survival of paregoric through the centuries, and particularly through recent critical decades, is probably due to keen clinical observation and stubborn adherence to the clinical deduction that paregoric is useful in certain types of cough.
The company’s mixture called Cholera Infantum, later renamed Pepto-Bismol, appeared for the first time in 1901. Its principal use was for infants with severe diarrhea. In 1907, Acetylsalicylic acid tablets were added to the company’s product line.
By 1926, John Boot had bought back the company and in 1927, renamed the Boots Pure Drug Company, it purchased a new 200-acre (81 ha) site at Beeston, outside of Nottingham, which became the Boots Factory Site. [3] Work began immediately and Owen Williams, an architect and engineer, was engaged to design a range of buildings on the site.