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107585 Ensembl ENSG00000197406 ENSMUSG00000075707 UniProt P55073 Q91ZI8 RefSeq (mRNA) NM_001362 NM_172119 RefSeq (protein) NP_001353 NP_742117 Location (UCSC) Chr 14: 101.56 – 101.56 Mb Chr 12: 110.25 – 110.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thyroxine 5-deiodinase also known as type III iodothyronine deiodinase (EC number 1.21.99.3) is an enzyme that in humans is ...
Iodothyronine deiodinases (EC 1.21.99.4 and EC 1.21.99.3) are a subfamily of deiodinase enzymes important in the activation and deactivation of thyroid hormones. Thyroxine (T 4), the precursor of 3,5,3'-triiodothyronine (T 3) is transformed into T 3 by deiodinase activity.
Three related isoforms, deiodinase type I, II, and III, contribute to activation and inactivation of the initially released hormone precursor T 4 into T 3 (triiodothyronine) or rT 3 (reverse triiodothyronine) in target cells. The enzymes catalyze a reductive elimination of iodine (the different isoforms attack different thyronine positions ...
This receptor-corepressor-DNA complex can block gene transcription. Triiodothyronine (T 3), which is the active form of thyroxine (T 4), goes on to bind to receptors. The deiodinase catalyzed reaction removes an iodine atom from the 5′ position of the outer aromatic ring of thyroxine's (T 4) structure. [64]
Download as PDF; Printable version; In other projects Wikidata item; Appearance. move to sidebar hide. Thyroxine deiodinase may refer to: Iodothyronine deiodinase ...
They inhibit release of thyroid hormones by the thyroid gland.The most studied drug in this class is lithium, which inhibits thyroid hormone secretion by inhibiting iodotyrosine coupling, thyroidal iodide uptake, and alteration in structure of thyroglobulin, [10] a protein which acts as a substrate for the synthesis of thyroid hormones and storage of inactive forms of T3, T4 and iodine within ...